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10 Best Supports for Vayne: Dominate Every Bot Lane
Posted: 15 May 2025

Did you know that pairing the right support with Vayne can increase your win rate by up to 15%? In "League of Legends," the right bot lane synergy can make all the difference.
Whether you're climbing the ranked ladder or playing casually, knowing the best supports for Vayne can greatly improve your game.
Vayne excels in the late game with her carry and damage. The right support can boost her strengths and help with her weaknesses. A good support can provide shields, healing, and more, turning the battle in your favor.

Key Takeaways:
- Choosing the best supports for Vayne can significantly boost your win rates.
- Supports with protective abilities and heals can enhance Vayne's sustainability in fights.
- Synergies that offer crowd control can maximize Vayne's effectiveness in the bot lane.
- Understanding the strengths of each support can help you dominate every match.
- Effective communication and coordination with your support are key for success.
Lulu: The Iconic Partner
Lulu is a key support in the game, pairing well with Vayne. Together, they form a strong team. Lulu's protection lets Vayne shine in tough battles.
Protective Abilities
Lulu's "Help, Pix!" shield is a game-changer. It keeps Vayne safe from harm. This shield also helps in long fights, making Lulu and Vayne a top duo.
Empowering Vayne
Lulu boosts Vayne's power too. "Whimsy" increases Vayne's attack speed and movement. This lets Vayne kite enemies better and deal more damage. Lulu is a great support for Vayne, helping her grow strong in the late game.
Ultimate Synergy
Lulu and Vayne's ultimate is a game-changer in team fights. Lulu's "Wild Growth" gives Vayne extra health and knocks up enemies. This turns the battle in your favor, making Vayne nearly unstoppable.
Milio: The Gentle Flame
Milio is a top choice for supporting Vayne. Known as the Gentle Flame, Milio helps Vayne shine. He boosts her attack range and heals her, making her play better.
Healing and Range Extension
Milio makes Vayne last longer in fights. His healing lets her stay in battles longer. He also increases her attack range, helping her get kills safely.
Crowd Control Immunity
Milio protects Vayne from crowd control. This lets her move freely and avoid danger. It's a key reason Milio is great for Vayne.
Ultimate Utility
Milio's ultimate helps Vayne a lot. It heals her and removes crowd control. This lets Vayne take advantage of enemy mistakes and move well. Milio is a top support for Vayne, helping her win the game.
Thresh: The Chain Warden
Thresh is a top pick for Vayne support. He excels at both protecting and engaging in battles. As a duo, you and Vayne can control the battlefield, turning fights in your favor.
Peel and Engage
Thresh's kit is full of engage tools like Death Sentence (Q) and Flay (E). These abilities let Vayne attack safely. Dark Passage (W) also helps, moving Vayne out of harm's way.
Zoning Capabilities
Thresh and Vayne can keep enemies at bay. This lets Vayne farm and trade effectively. Enemies fear Thresh's hooks, staying far away. This keeps Vayne safe in fights.
Utility Skills
Thresh's skills are incredibly useful for Vayne. His lantern helps in escapes and quick repositions. The Box (R) ultimate adds to your crowd control, letting Vayne deal more damage.
Nami: The Ocean's Blessing
Nami support Vayne, offers a mix of healing, damage boost, and crowd control. This combo can greatly enhance Vayne's performance in the bot lane. Together, they can overpower opponents with perfect teamwork.
Healing and Sustain
In the early game, Nami shines by healing and sustaining Vayne with her W, Ebb and Flow. This keeps Vayne alive longer in fights and lets her farm more. It gives her an advantage over foes.
Additive Magic Damage
Nami's E, Tidecaller's Blessing, adds magic damage and slows down enemies. This boosts Vayne's attacks, making her even more deadly.
Reliable Crowd Control
Nami's Q, Aqua Prison, and ultimate, Tidal Wave, offer strong crowd control. This lets Vayne take advantage of immobilized foes. It's a key part of their bot lane success.
Senna: The Redeemer
When Senna supports Vayne, they form a strong duo. They excel in both offense and utility. Senna's unique playstyle complements Vayne's, making her even more powerful.
Semi-ADC Support
Senna acts as a semi-ADC support, dealing damage and providing backline support. This is perfect for Vayne, who gets more pressure from Senna. Together, they can control the game's pace.
Healing and Poke
Senna keeps Vayne healthy with her healing and long-range attacks. Her Piercing Darkness damages foes and heals allies. This lets Vayne stay aggressive and farm safely.
Ultimate Protection
Senna's ultimate, Dawning Shadow, offers protection and damage from afar. It shields Vayne, letting her stay in fights longer. This boosts Vayne's effectiveness, making Senna a key ally.
Janna: The Storm’s Fury
Janna is a great support for Vayne in the bot lane. She is one of the top supportive champions in League of Legends. Her kit makes Vayne more mobile and survivable.
Shield and Speed Boost
With Janna, Vayne gets a strong defensive boost. Her Eye of the Storm ability gives a shield that absorbs damage and boosts attack damage. This lets Vayne win fights easily.
Janna's Tailwind passive also increases movement speed. This helps Vayne move fast and avoid danger.
Disengage Tools
Janna is great at disengaging and controlling the battlefield. Her Howling Gale ability knocks up and slows enemies. This creates space for Vayne to stay safe.
This is very useful when enemies try to dive or attack aggressively.
Ultimate Reset
Janna's Monsoon ultimate can change the game. It heals allies and pushes enemies away. This can save battles or help in tough situations.
It shows why Janna is among the best supportive champions in League of Legends.
Blitzcrank: The Great Steam Golem
Pairing Vayne with Blitzcrank adds excitement to the bot lane. Blitzcrank's hook can change the fight's direction, making him a top support for Vayne. He pulls enemies out of place, allowing Vayne to attack them quickly.
Hook Potential
The Rocket Grab is Blitzcrank's signature move. It can grab important enemies, setting them up for Vayne's deadly attacks. A successful hook gives Vayne a chance to kill fast and take control of the lane.
Disruption Abilities
Blitzcrank has more than just his hook. His Power Fist knocks enemies up, controlling the battlefield. This helps Vayne move and deal more damage. Blitzcrank keeps enemies on the back foot, making them defensive.
Ultimate Silences
Blitzcrank's Static Field ultimate silences enemies in range. This stops them from using key spells, letting Vayne attack without interruption. Blitzcrank and Vayne together put pressure on the enemy team, often leading to wins.
Alistar: The Minotaur
Alistar is a top choice for a tank support with Vayne. His strong presence in the bot lane opens up many chances for Vayne to excel.
Tankiness and Hard Engage
Alistar and Vayne together can change the game. His toughness and ability to engage hard are key. His combo of Pulverize and Headbutt can mess up the enemy's plan.
This lets Vayne move and fire her Silver Bolts. You can take over the bot lane, making it hard for enemies to fight back.
Healing and Sustain
Alistar is not just a tank; he also heals. His passive, Triumphant Roar, heals him and his allies. This means you and Vayne can last longer in fights.
His healing and crowd control help you beat your opponents in the lane.
Ultimate Damage Reduction
Alistar's ultimate, Unbreakable Will, is a game-changer. It makes him almost unbeatable in team fights. This lets him protect Vayne while she attacks.
With Alistar's help, Vayne can show her true power without worrying about damage.
Rakan: The Charmer
Rakan and Vayne make a perfect team in the bot lane. Rakan's quick movements help you dodge enemy attacks. This makes it hard for them to hit Vayne.
His fast and agile actions help Vayne move and kite smoothly. This is key for Vayne to stay safe and deal damage.
High Mobility
Rakan's speed is a big advantage for Vayne. He can quickly move between allies and enemies. This keeps you ahead of the enemy team.
His speed lets you protect Vayne from harm. This gives Vayne chances to deal lots of damage.
AoE Crowd Control
Rakan's crowd control is very powerful. His area-of-effect abilities can hold down many enemies at once. This helps Vayne deal more damage.
This teamwork is key for Vayne to shine. It keeps enemies trapped in Rakan's control, making it hard for them to escape.
Ultimate Engage
Rakan's ultimate, The Quickness, is a game-changer in fights. It charms and freezes enemies, setting up Vayne for a big attack. This is how Rakan and Vayne dominate the bot lane.
Together, they create a strong and deadly team. Their agility and power make the bot lane a fortress.
Taric: The Shield of Valoran
Looking for top-notch protection for Vayne? Taric is your best bet. He's a top protective support in League of Legends, making Vayne more durable and effective in fights.
Shields and Heals
Taric's shields and heals keep Vayne alive in tough battles. His Bastion skill shields both of you, boosting Vayne's defense and keeping her fighting longer.
AoE Stuns
Taric's Dazzle is a strong crowd control tool. It can stun enemies, giving Vayne a chance to attack safely. This stun can be a big advantage in team fights, stopping enemies from attacking back.
Invulnerability Ultimate
Taric's ultimate, Cosmic Radiance, is a game-changer. It makes Vayne and her allies invulnerable for a short time. This lets Vayne attack enemies without fear, changing the battle's outcome.
Using Taric as Vayne's support makes her a powerful force on the battlefield. Taric offers unmatched protection and utility. He's the best protective support in League of Legends, providing essential damage reduction, crowd control, and invincibility.
Conclusion
In your journey to dominate the bot lane as Vayne, understanding the synergy between her and her support champions is key. Each support brings unique abilities that can boost Vayne’s power. This ensures your team has a strategic edge.
By choosing the best supports for Vayne, like Lulu's protection or Thresh's peeling, you can tailor your gameplay. This helps neutralize threats and increase your damage.
Thresh’s versatile engage and peel, Nami's healing and crowd control, and Senna's poke and semi-ADC support are all critical. Enchanters like Janna and tanks like Alistar add the balance of offense and defense. They empower Vayne in key moments of any match.
The strategic play and synergy between Vayne and her supports are essential for winning bot lane combos. By using your support's strengths, you can dominate the lane and influence the match's outcome. The right support can enhance Vayne’s strengths and reduce her weaknesses, leading to victory in the Rift.
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